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Epigentek 創(chuàng)新技術(shù)和表觀遺傳學(xué)-相關(guān)技術(shù)文章

更新時(shí)間：2024-07-17

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Epigentek 創(chuàng)新技術(shù)和表觀遺傳學(xué)

Epigentek集團(tuán)公司是全球創(chuàng)新技術(shù)和表觀遺傳學(xué)相關(guān)研究產(chǎn)品的開(kāi)發(fā)商和供應(yīng)商。公司開(kāi)發(fā)了包括400多個(gè)產(chǎn)品的全面的產(chǎn)品組合，為表觀遺傳學(xué)方面的研究和新藥研發(fā)提供全面系統(tǒng)的解決方案。2019年，Epigentek榮獲“Bioz Rising Star^TM",被評(píng)為2019表觀遺傳學(xué)領(lǐng)域的新星公司。

Epigentek公司的產(chǎn)品銷(xiāo)售領(lǐng)域

全shi界的備受推崇的學(xué)者、制藥企業(yè)以及很多專(zhuān)業(yè)的生物技術(shù)公司都在使用Epigentek產(chǎn)品。相比普通方法的產(chǎn)品而言，這些du特的產(chǎn)品在科研分析過(guò)程中更簡(jiǎn)單、更快捷、更方便、更有效。Epigentek公司的產(chǎn)品通過(guò)專(zhuān)門(mén)的銷(xiāo)售隊(duì)伍和遍布全球超過(guò)36個(gè)國(guó)家和地區(qū)的經(jīng)銷(xiāo)商進(jìn)行銷(xiāo)售。讓客戶滿意和幫助客戶在試驗(yàn)中取得最大成功是我們進(jìn)行技術(shù)創(chuàng)新的首要任務(wù)。公司特別強(qiáng)調(diào)技術(shù)的速度和效率，繼續(xù)側(cè)重于表觀遺傳學(xué)創(chuàng)新和廣泛發(fā)展，提高其產(chǎn)品組合。

Epigentek公司的產(chǎn)品類(lèi)型

專(zhuān)業(yè)提供DNA甲基化試劑盒、組蛋白修飾相關(guān)試劑盒、染色質(zhì)免疫沉淀反應(yīng)試劑盒、基因表達(dá)與沉默檢測(cè)試劑盒、DNA損傷及修復(fù)試劑盒、SUMO化修飾分析試劑盒、表型相關(guān)抗體等表觀遺傳學(xué)產(chǎn)品。

蛋白質(zhì)與DNA之間的動(dòng)態(tài)相互作用，參與并推動(dòng)了基因的表達(dá)、調(diào)控、復(fù)制、重組和修復(fù)以及RNA的轉(zhuǎn)運(yùn)、翻譯和調(diào)控等多個(gè)生物學(xué)過(guò)程，幾乎涉及所有的生命活動(dòng)。繪制這些蛋白質(zhì)-DNA結(jié)合事件發(fā)生的時(shí)空關(guān)系，對(duì)于正常發(fā)育和疾病中表觀遺傳學(xué)的機(jī)理研究至關(guān)重要。

為了生成這種數(shù)據(jù)，科學(xué)家通常使用ChIP（染色質(zhì)免疫沉淀）-Seq法。傳統(tǒng)的ChIP-Seq實(shí)驗(yàn)需要花費(fèi)三天來(lái)完成：首先進(jìn)行染色質(zhì)交聯(lián)（使用甲醛作為交聯(lián)劑），使基因組上分布的蛋白以及各種修飾定格下來(lái)，然后對(duì)交聯(lián)的染色質(zhì)進(jìn)行超聲裂解，再利用抗原抗體特異性反應(yīng)將與目的蛋白相結(jié)合的DNA片段沉淀下來(lái)，再進(jìn)行解交聯(lián)釋放結(jié)合蛋白的DNA片段，最后對(duì)獲得的DNA片段進(jìn)行測(cè)序分析。這些繁瑣的步驟中會(huì)大量損失樣本和信息，因此傳統(tǒng)的ChIP-Seq方法具有需要大量細(xì)胞、重復(fù)性差、低信號(hào)、高背景等缺點(diǎn)。

2017年，Henikoff博士及其實(shí)驗(yàn)室的研究人員在eLife雜志上發(fā)表了一種稱(chēng)為CUT&RUN的新方法。CUT&RUN（Cleavage Under Targets and Release Using），即核酸酶靶向切割及釋放技術(shù)。CUT&RUN技術(shù)的出現(xiàn)，克服了傳統(tǒng)ChIP-seq方法的缺陷，可以在細(xì)胞天然染色質(zhì)環(huán)境下進(jìn)行蛋白-DNA互作的研究。

Epigentek公司的熱銷(xiāo)產(chǎn)品

產(chǎn)品名稱(chēng)	貨號(hào)	規(guī)格
MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric)	P-1034-96	96 Assays
EpiQuik Total Histone Extraction Kit	OP-0006-100	100 Extractions
EpiQuik Nuclear Extraction Kit	OP-0002-1	100 Assays
BisulFlash DNA Modification Kit	P-1026-050	50 Reactions
EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit	P-3001-1	48 Assays
MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric)	P-1034-48	48 Assays
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)	P-9005-96	96 Reactions
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)	P-9005-48	48 Reactions
MethylFlash Hydroxymethylated DNA 5-hmC Quantification Kit (Colorimetric)	P-1036-96	96 Assays
EpiQuik Chromatin Immunoprecipitation (ChIP) Kit	P-2002-1	24 Reactions
Methylamp DNA Modification Kit	P-1001-2	80 Reactions
MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric)	P-1030-96	96 reactions
MethylFlash Methylated DNA Quantification Kit (Fluorometric)	P-1035-96	96 Assays
EpiQuik Plant ChIP Kit	P-2014-48	48 Reactions
5-Methylcytosine (5-mC) Monoclonal Antibody [33D3]	A-1014-050	50 ug
Methylamp Global DNA Methylation Quantification Ultra Kit	P-1014B-48	48 Assays
Methylamp DNA Modification Kit	P-1001-1	40 Reactions
Methylamp Global DNA Methylation Quantification Ultra Kit	P-1014B-96	96 Assays
EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric)	P-3009-48	48 Assays
EpiQuik Plant ChIP Kit	P-2014-24	24 Reactions
MethylFlash Hydroxymethylated DNA 5-hmC Quantification Kit (Colorimetric)	P-1036-48	48 Assays
Methylamp Methylated DNA Capture (MeDIP) Kit	P-1015-48	48 Reactions
EpiQuik 8-OHdG DNA Damage Quantification Direct Kit (Colorimetric)	P-6003-96	96 Assays
Epigenase HDAC Activity/Inhibition Direct Assay Kit (Colorimetric)	P-4034-96	96 Assays
EpiQuik Tissue Chromatin Immunoprecipitation (ChIP) Kit	P-2003-1	24 Reactions
MethylFlash Hydroxymethylated DNA Quantification Kit (Fluorometric)	P-1037-96	96 Assays
MethylFlash Methylated DNA Quantification Kit (Fluorometric)	P-1035-48	48 Assays
EpiQuik Total Histone H3 Acetylation Detection Fast Kit (Colorimetric)	P-4030-96	96 Assays
Methylamp Whole Cell Bisulfite Modification Kit	P-1016-80	80 Samples
EpiQuik Total Histone H4 Acetylation Detection Fast Kit (Colorimetric)	P-4032-96	96 Assays
EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit	P-3001-2	96 Assays
EpiQuik Global Histone H3 Acetylation Assay Kit	P-4008-96	96 Assays
Histone H3K9me3 (H3K9 Trimethyl) Polyclonal Antibody	A-4036-025	25 ul
EpiQuik Chromatin Immunoprecipitation (ChIP) Kit	P-2002-2	48 Reactions
EpiQuik HDAC Activity/Inhibition Assay Kit (Colorimetric)	P-4002-96	96 Assays
EpiQuik MeDIP Ultra Kit	P-1052-48	48 Reactions
5-Methylcytosine (5-mC) Monoclonal Antibody [33D3]	A-1014-010	10 ug
EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric)	P-3009-96	96 Assays
EpiQuik Hydroxymethylated DNA Immunoprecipitation (hMeDIP) Kit	P-1038-24	24 Reactions
EpiQuik Global Histone H4 Acetylation Assay Kit	P-4009-96	96 Assays
EpiQuik One-Step DNA Hydrolysis Kit	P-1023-96	96 Samples
EpiQuik Global Histone H3 Acetylation Assay Kit	P-4008-48	48 Assays
EpiQuik Global Histone H4 Acetylation Assay Kit	P-4009-48	48 Assays
5-Methylcytosine (5-mC) Monoclonal Antibody [33D3]	A-1014-100	100 ug
Histone H3K9me2 (H3K9 Dimethyl) Polyclonal Antibody	A-4035-050	50 ul
Histone H3K27me3 (H3K27 Trimethyl) Polyclonal Antibody	A-4039-025	25 ul
EpiQuik Tissue Acetyl-Histone H3 ChIP Kit	P-2012-24	24 Reactions
EpiQuik Dnmt1 Assay Kit	P-3011-2	48 Assays
EpiQuik HAT Activity/Inhibition Assay Kit	P-4003-96	96 Assays
EpiQuik Tissue Chromatin Immunoprecipitation (ChIP) Kit	P-2003-2	48 Reactions